Therapeutic potential of organometallic compounds in the cancer treatment. A short review
DOI:
https://doi.org/10.37135/unach.ns.001.01.02Keywords:
Therapeutics agents, cancer, organometallic compounds, ligands, transition metalsAbstract
According to the World Health Organization (WHO), cancer is the second cause of death in the world, almost one out of every six deaths globally is due to this disease. In chemistry area, efforts are being made to better investigate anticancer compounds, and organometallic reagents offer an interesting opportunity, for a synergistic effect between the medicinal properties of the ligands and the chemical characteristics of the transition metals. In this article, we present a short review of some advances in anticancer organometallic compounds. The review indicates that small structural changes implicate large changes in anticancer activity, which generates new possibilities more specific chemotherapies, with less side-effects and economically more affordable.
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References
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- Gasser, G., Ott, I. & Metzler-Nolte, N., (2011) Organometallic Anticancer Compounds. Journal of Medicinal Chemistry, 54, 3-25.
- Geiger, W.R. (2007). Organometallic Electrochemistry: Origins, Development, and Future. Organometallics, 24, 5738-5765.
- Hanif, M., Babak, M.B. & Hartinger, Ch.G. (2014). Development of anticancer agents: wizardry with osmium. Drug Discovery Today, 19(10), 1640-1648.
- Harry, A.G., Butler, W.E., Manton, J.C., Pryce, M.T., O’Donovan, N., Crown, J., Rai, D.K. & Kenny, P.T.M. (2014). The synthesis, structural characterization and in vitro anticancer activity of novel 1-alkyl-10-N-para-(ferrocenyl) benzoyl dipeptide esters. Journal of Organometallic Chemistry, 757, 28-35.
- Harry, A.G., Murphy, J.P., O'Donovan, N., Crown, J., Rai, D.K. & Kenny, P.T.M. (2017). The synthesis, structural characterization and biological evaluation of novel N-{para-(ferrocenyl) ethynyl benzoyl} amino acid and dipeptide methyl and ethyl esters as anticancer agents. Journal of Organometallic Chemistry, 846, 379-388.
- Hillard, E.A. & Jaouen, G. (2011). Bioorganometallics: Future Trends in Drug Discovery, Analytical Chemistry, and Catalysis. Organometallics, 30(1), 20-27.
- Huang, K-B., Wang, F-Y., Tang, X-M., Feng, H-W., Chen, Z-F., Liu, Y-Ch., Liu, Y-N. & Liang, H. (2018). Organometallic Gold(III) Complexes Similar to Tetrahydroisoquinoline Induce ER-Stress-Mediated Apoptosis and Pro-Death Autophagy in A549 Cancer Cells. Journal of Medicinal Chemistry, 61, 3478-3490.
- Jaouen, G. & Salmain, M., (2015). Bioorganometallic Chemistry: Applications in Drug Discovery, Biocatalysis, and Imaging. Weinheim: Wiley-VCH.
- Klajner, M., Licona, C., Fetzer, L., Hebraud, P., Mellitzer, G., Pfeffer, M., Harlepp, S. & Gaiddon, C. (2014). Subcellular Localization and Transport Kinetics of Ruthenium Organometallic Anticancer Compounds in Living Cells: A Dose-Dependent Role for Amino Acid and Iron Transporters. Inorganic Chemistry, 53, 5150−5158.
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- Kowalski, K. (2016). Ferrocenyl-nucleobase complexes: Synthesis, chemistry and applications. Coordination Chemistry Reviews, 317:132-156.
- Lawrance, G.A. (2010). Introduction to coordination chemistry. Wiltshire: Wiley.
- Lazarevic, T., Rilak, A. & Bugarcic, Z.D. (2017). Platinum, palladium, gold and ruthenium complexes as anticancer agents: Current clinical uses, cytotoxicity studies and future perspectives. European Journal of Medicinal Chemistry, 142, 8-31.
- Ruiz, J., Vicente, C., de Haro, C. & Bautista, D. (2013). Novel Bis-C, N-Cyclometalated Iridium(III) Thiosemicarbazide Antitumor Complexes: Interactions with Human Serum Albumin and DNA, and Inhibition of Cathepsin B. Inorganic Chemistry, 52(2), 974-982.
- Leonidova, A. & Gasser, G. (2014). Underestimated Potential of Organometallic Rhenium Complexes as Anticancer Agents. ACS Chemcal Biology, 9(10), 2180-2193.
- Lianga, J-H., Zhonga, H-J., Yanga, G., Vellaisamy, K., Ma, D-L. & Leung Ch-H. (2017). Recent development of transition metal complexes with in vivo antitumor activity. Journal of Inorganic Biochemistry, 177, 276-286.
- Liu, Z., Romero-Canelón, I., Habtemariam, A., Clarkson, G.J. & Sadler, P.J. (2014). Potent Half-Sandwich Iridium(III) Anticancer Complexes Containing C∧N-Chelated and Pyridine Ligands. Organometallics, 33(19), 5324–5333.
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- Meier, S.M., Hanif, M., Adhireksan, Z., Pichler, V., Novak, M., Jirkovsky, E., Jakupec, M.A., Arion, V.B., Davey, C.A., Kepplera, B.K. & Hartinger, Ch.G. (2013). Novel metal(II) arene 2-pyridinecarbothioamides: a rationale to orally active organometallic anticancer agents. Chemical Science, 4, 1837-1846.
- Morris, R.E., Aird, R.E., Murdoch, P.S., Chen, H., Cummings, J., Hughes, N.D., Parsons, S., Parkin, A., Boyd, G., Jodrell, D.I. & Sadler, P.J. (2001). Inhibition of Cancer Cell Growth by Ruthenium(II) Arene Complexes. Journal of Medicinal Chemistry, 44, 3616-3621.
- Muetterties, E.L., Bleeke, J.L., Wucherer, E.J. & Albright, T.A. (1982). Structural, Stereochemical, and Electronic Features of Arene-Metal Complexes. Chemical Review, 82, 499-525.
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- Naciones Unidas. (2016). Objetivos de Desarrollo Sostenible, Informe 2016. Nueva York: ONU.
- Noble, B. & Peacock, R.D. (1996). Absorption, Circular Dichroism, and Luminescence Spectroscopy of Electrogenerated Δ-(Ru(bipy)3)+/0/- and Δ-(Os(bipy)3)+/0/- (bipy = 2,2‘-Bipyridine). Inorganic Chemistry, 35(6), 1616-1620
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- Pucci, D., Albertini, V., Bloise, R., Bellusci, A., Cataldi, A., Catapano, C.V., Ghedini, M. & Crispini., A. (2006). Synthesis and anticancer activity of cyclopalladated complexes containing 4-hydroxy-acridine. Journal of Inorganic Biochemistry, 100, 1575-1578.
- Santini, S., Pellei, M., Gandin, V., Porchia, M., Tisato, F. & Marzano, C. (2014). Advances in Copper Complexes as Anticancer Agents. Chemical Reviews, 114(1), 815-862.
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- Southam, H.M., Butler, J.A., Chapman, J.A. & Poole, R.K. (2017). The Microbiology of Ruthenium Complexes. Advances in Microbial Physiology, 71, 1-96.
- Suntharalingam, K., Johnstone, T.C., Bruno, P.M., Lin, W., Hemann, M.T. & Lippard, S.J. (2014). Bidentate Ligands on Osmium(VI) Nitrido Complexes Control Intracellular Targeting and Cell Death Pathways. Journal of the American Chemical Society, 135(38), 14060−14063.
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Published
2018-06-12
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Research Articles and Reviews
How to Cite
Therapeutic potential of organometallic compounds in the cancer treatment. A short review. (2018). Novasinergia, ISSN 2631-2654, 1(1), 14-22. https://doi.org/10.37135/unach.ns.001.01.02
