Compuestos Organometálicos y su potencial terapéutico en el tratamiento del cáncer. Una breve revisión
DOI:
https://doi.org/10.37135/unach.ns.001.01.02Palabras clave:
Agentes terapéuticos, cáncer, compuestos organometálicos, ligantes, metales de transiciónResumen
Según la Organización Mundial de la Salud (OMS), el cáncer es la segunda causa de muerte a nivel global, y casi una de cada seis defunciones en el mundo se debe a esta enfermedad. Desde la química se hacen esfuerzos por investigar mejores agentes terapéuticos contra el cáncer y los compuestos organometálicos ofrecen una interesante oportunidad, en base al efecto sinérgico entre las propiedades medicinales de los ligantes y las características químicas de los metales de transición. En este artículo se presenta una breve revisión de algunos avances en compuestos organometálicos utilizados en el tratamiento del cáncer. La revisión pone de manifiesto que, pequeños cambios estructurales, se traducen en grandes cambios de la actividad anticancerígena, lo cual genera nuevas posibilidades para quimioterapias más específicas, con menores efectos secundarios y económicamente más asequibles.
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Referencias
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- Berger, G., Grauwet, K., Zhang, H., Hussey, A.M., Nowicki, M.O., Wang, D.I., Chiocca, E.A., Lawler, S.E. & Lippard, S.J. (2018). Anticancer activity of osmium(VI) nitrido complexes in patient-derived glioblastoma initiating cells and in vivo mouse models. Cancer Letters, 416, 138-148.
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- Braga, S.S. & Silva, A.M.S., (2013). A New Age for Iron: Antitumoral Ferrocenes. Organometallics, 32(20), 5626-5639.
- Buchel, K.H., Moretto, H-H. & Woditsch,P. (2003). Industrial Inorganic Chemistry. Weinheim: Wiley-VCH.
- Calderazzo, F. (1990). Organometallic derivatives of palladium, platinum, and gold. Journal of Organometallic Chemistry, 400(1-2), 303-320.
- Chirik, P.J. (2010). Group 4 Transition Metal Sandwich Complexes: Still Fresh after Almost 60 Years. Organometallics, 29 (7), 1500-1517.
- Contreras, R.R. & Cardozo, E. (2015). Conceptos de nanoquímica. Capítulo 1, p. 1-28. En: Lárez-Velásquez, C., Koteich-Khatib, S., López-González, F. (Editores). Nanotecnología: Fundamentos y Aplicaciones. Avances en Química. Mérida: Departamento de Química – ULA.
- Contreras, R.R. (2014). Materiales híbridos: una aproximación a la química de los compuestos organometálicos. Mérida: Ediciones del CDCHTA-ULA.
- Contreras, R.R., Aranguren, J.N., Bellandi, F. & Gutiérrez, A. (2012). Una nueva generación de fármacos a base de compuestos organometálicos. CIENCIA, 20 (Número especial), 15-24.
- Contreras, RR. (2012). Conozca más los alimentos. Mérida. Ediciones ULA, Vicerrectorado Académico.
- Cornils, B. & Herrmann, W.A. (2017). Applied Homogeneous Catalysis with Organometallic Compounds. Weinheim: Wiley-VCH.
- Crabtree, R.H. (2014). The Organometallic Chemistry of the Transition Metals (6th Edition). New Jersey: Wiley.
- Cornils, B. & Herrmann, W.A. (2004). Aqueous-Phase Organometallic Catalysis: Concepts and Applications. Weinheim. Wiley-VCH.
- Cutillas, N., Yellol, G.S., de Haro, C., Vicente, C., Rodríguez, V. & Ruiz, J. (2013). Anticancer cyclometalated complexes of platinum group metals and gold. Coordination Chemistry Reviews, 257(19-20), 2784-2797.
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- de la Cueva-Alique, A., Muñoz-Moreno, L., Benabdelouahab, Y., Elie, BE., El Amrani, MA., Mosquera, MEG., Contel, M., Bajo, AM., Cuenca, T. & Royo, E. (2016). Novel enantiopure cyclopentadienyl Ti(IV) oximato compounds as potential anticancer agents. Journal of Inorganic Biochemistry, 156, 22-34.
- Donzello, M.P., Vittori, D., Viola, E., Manet, I., Mannina, L., Cellai, L., Monti, S. & Ercolani, C. (2011). Tetra-2,3-pyrazinoporphyrazines with Externally Appended Pyridine Rings. 9. Novel Heterobimetallic Macrocycles and Related Hydrosoluble Hexacations as Potentially Active Photo/Chemotherapeutic Anticancer Agents. Inorganic Chemistry. 50(16), 7391-7402.
- Fernández-Gallardo, J., Elie, B.T., Sulzmaier, F.J., Sanaú, M., Ramos, J.W. & Contel, M. (2014). Organometallic Titanocene-Gold Compounds as Potential Chemotherapeutics in Renal Cancer. Study of their Protein Kinase Inhibitory Properties. Organometallics, 33, 6669-6681.
- Fontal, B. (traductor). (2005). Enfrentando los Elementos. Mérida: Ediciones del Vicerrectorado Académico de la Universidad de Los Andes.
- Galanski, M., Arion, V.B., Jakupec, M.A. & Keppler, B. K. (2003). Recent Developments in the Field of Tumor-Inhibiting Metal Complexes. Current Pharmaceutical Design, 9, 2078-2089.
- Gasser, G., Ott, I. & Metzler-Nolte, N., (2011) Organometallic Anticancer Compounds. Journal of Medicinal Chemistry, 54, 3-25.
- Geiger, W.R. (2007). Organometallic Electrochemistry: Origins, Development, and Future. Organometallics, 24, 5738-5765.
- Hanif, M., Babak, M.B. & Hartinger, Ch.G. (2014). Development of anticancer agents: wizardry with osmium. Drug Discovery Today, 19(10), 1640-1648.
- Harry, A.G., Butler, W.E., Manton, J.C., Pryce, M.T., O’Donovan, N., Crown, J., Rai, D.K. & Kenny, P.T.M. (2014). The synthesis, structural characterization and in vitro anticancer activity of novel 1-alkyl-10-N-para-(ferrocenyl) benzoyl dipeptide esters. Journal of Organometallic Chemistry, 757, 28-35.
- Harry, A.G., Murphy, J.P., O'Donovan, N., Crown, J., Rai, D.K. & Kenny, P.T.M. (2017). The synthesis, structural characterization and biological evaluation of novel N-{para-(ferrocenyl) ethynyl benzoyl} amino acid and dipeptide methyl and ethyl esters as anticancer agents. Journal of Organometallic Chemistry, 846, 379-388.
- Hillard, E.A. & Jaouen, G. (2011). Bioorganometallics: Future Trends in Drug Discovery, Analytical Chemistry, and Catalysis. Organometallics, 30(1), 20-27.
- Huang, K-B., Wang, F-Y., Tang, X-M., Feng, H-W., Chen, Z-F., Liu, Y-Ch., Liu, Y-N. & Liang, H. (2018). Organometallic Gold(III) Complexes Similar to Tetrahydroisoquinoline Induce ER-Stress-Mediated Apoptosis and Pro-Death Autophagy in A549 Cancer Cells. Journal of Medicinal Chemistry, 61, 3478-3490.
- Jaouen, G. & Salmain, M., (2015). Bioorganometallic Chemistry: Applications in Drug Discovery, Biocatalysis, and Imaging. Weinheim: Wiley-VCH.
- Klajner, M., Licona, C., Fetzer, L., Hebraud, P., Mellitzer, G., Pfeffer, M., Harlepp, S. & Gaiddon, C. (2014). Subcellular Localization and Transport Kinetics of Ruthenium Organometallic Anticancer Compounds in Living Cells: A Dose-Dependent Role for Amino Acid and Iron Transporters. Inorganic Chemistry, 53, 5150−5158.
- Kauffman, G.B. (1983). The Discovery of Ferrocene, the First Sandwich Compound. Journal of Chemical Education, 60, 185-186.
- Kowalski, K. (2016). Ferrocenyl-nucleobase complexes: Synthesis, chemistry and applications. Coordination Chemistry Reviews, 317:132-156.
- Lawrance, G.A. (2010). Introduction to coordination chemistry. Wiltshire: Wiley.
- Lazarevic, T., Rilak, A. & Bugarcic, Z.D. (2017). Platinum, palladium, gold and ruthenium complexes as anticancer agents: Current clinical uses, cytotoxicity studies and future perspectives. European Journal of Medicinal Chemistry, 142, 8-31.
- Ruiz, J., Vicente, C., de Haro, C. & Bautista, D. (2013). Novel Bis-C, N-Cyclometalated Iridium(III) Thiosemicarbazide Antitumor Complexes: Interactions with Human Serum Albumin and DNA, and Inhibition of Cathepsin B. Inorganic Chemistry, 52(2), 974-982.
- Leonidova, A. & Gasser, G. (2014). Underestimated Potential of Organometallic Rhenium Complexes as Anticancer Agents. ACS Chemcal Biology, 9(10), 2180-2193.
- Lianga, J-H., Zhonga, H-J., Yanga, G., Vellaisamy, K., Ma, D-L. & Leung Ch-H. (2017). Recent development of transition metal complexes with in vivo antitumor activity. Journal of Inorganic Biochemistry, 177, 276-286.
- Liu, Z., Romero-Canelón, I., Habtemariam, A., Clarkson, G.J. & Sadler, P.J. (2014). Potent Half-Sandwich Iridium(III) Anticancer Complexes Containing C∧N-Chelated and Pyridine Ligands. Organometallics, 33(19), 5324–5333.
- Lloyd, N.C., Morgan, H.W., Nicholson, B.K. & Ronimus, R.S., (2005). The composition of Ehrlich's salvarsan: resolution of a century-old debate. Angewandte Chemie, 44(6), 941-944.
- Meléndez, E. (2012). Metallocenes as target specific drugs for cancer treatment. Inorganica Chimica Acta, 393, 36–52.
- Meier, S.M., Hanif, M., Adhireksan, Z., Pichler, V., Novak, M., Jirkovsky, E., Jakupec, M.A., Arion, V.B., Davey, C.A., Kepplera, B.K. & Hartinger, Ch.G. (2013). Novel metal(II) arene 2-pyridinecarbothioamides: a rationale to orally active organometallic anticancer agents. Chemical Science, 4, 1837-1846.
- Morris, R.E., Aird, R.E., Murdoch, P.S., Chen, H., Cummings, J., Hughes, N.D., Parsons, S., Parkin, A., Boyd, G., Jodrell, D.I. & Sadler, P.J. (2001). Inhibition of Cancer Cell Growth by Ruthenium(II) Arene Complexes. Journal of Medicinal Chemistry, 44, 3616-3621.
- Muetterties, E.L., Bleeke, J.L., Wucherer, E.J. & Albright, T.A. (1982). Structural, Stereochemical, and Electronic Features of Arene-Metal Complexes. Chemical Review, 82, 499-525.
- Naciones Unidas. (2000). Declaración del Milenio. Nueva York: ONU.
- Naciones Unidas. (2016). Objetivos de Desarrollo Sostenible, Informe 2016. Nueva York: ONU.
- Noble, B. & Peacock, R.D. (1996). Absorption, Circular Dichroism, and Luminescence Spectroscopy of Electrogenerated Δ-(Ru(bipy)3)+/0/- and Δ-(Os(bipy)3)+/0/- (bipy = 2,2‘-Bipyridine). Inorganic Chemistry, 35(6), 1616-1620
- Patrick, G. (2017). An Introduction to Medicinal Chemistry. Oxford: Oxford University Press.
- Pucci, D., Albertini, V., Bloise, R., Bellusci, A., Cataldi, A., Catapano, C.V., Ghedini, M. & Crispini., A. (2006). Synthesis and anticancer activity of cyclopalladated complexes containing 4-hydroxy-acridine. Journal of Inorganic Biochemistry, 100, 1575-1578.
- Santini, S., Pellei, M., Gandin, V., Porchia, M., Tisato, F. & Marzano, C. (2014). Advances in Copper Complexes as Anticancer Agents. Chemical Reviews, 114(1), 815-862.
- Sava G., Alessio E., Bergamo A. & Mestroni G. (1999) Sulfoxide Ruthenium Complexes: Non-Toxic Tools for the Selective Treatment of Solid Tumour Metastases. En: Clarke M.J., Sadler P.J. (eds.) Metallopharmaceuticals I. Topics in Biological Inorganic Chemistry, vol 1. Springer, Berlin, Heidelberg.
- Southam, H.M., Butler, J.A., Chapman, J.A. & Poole, R.K. (2017). The Microbiology of Ruthenium Complexes. Advances in Microbial Physiology, 71, 1-96.
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Archivos adicionales
Publicado
2018-06-12
Número
Sección
Artículos de Investigación y Artículos de Revisión
Cómo citar
Compuestos Organometálicos y su potencial terapéutico en el tratamiento del cáncer. Una breve revisión. (2018). Novasinergia, ISSN 2631-2654, 1(1), 14-22. https://doi.org/10.37135/unach.ns.001.01.02
